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Insulin is only released when blood glucose is elevated, reducing hypoglycemia risk compared to sulfonylureas or exogenous insulin

Specifically, the relative risks were reduced by approximately 37% for Alzheimers disease, 41% for Lewy body dementia, and 56% for vascular dementia

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10.1001/jama.2023.24945

Whole bone loss is influenced by initial body weight, age, sex, physical activity, extent of energy restriction, and rate of weight reduction, with older individuals and women experiencing greater bone loss [67]