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However, this increased risk of retinopathy was neither replicated in other semaglutide trials nor recorded with other GLP-1RAs [70]

[13] [11] Other GLP-1 receptor agonists have demonstrated renoprotective effects in dedicated outcome trials, though these findings cannot be automatically extrapolated to tirzepatide

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But to be on the safe side, systemic hormone therapy is generally not advised for women who have a history of breast cancer, especially if theyre hormone receptor positive

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Notably, the 2024 FDA approval of Wegovy for cardiovascular risk reduction in adults with established cardiovascular disease and obesity/overweight (based on the SELECT trial) provides additional evidence of cardiometabolic benefits beyond glycemic control