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No definitive studies exist, but case reports suggest this may be a real issue

Dose calculation errors

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Cardiol Rev 101097 Thomsen M, Holst JJ, Molander A et al (2019) Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring Vervet monkeys

It also explains retatrutide's unique side effect: dysesthesia (abnormal skin sensations) is seen only in retatrutide users, not tirzepatide or semaglutide users, and is likely related to glucagon receptor activation or its downstream metabolic effects

Morning Tirzepatide Injections: Benefits and Drawbacks Injecting tirzepatide in the morning aligns with peak cortisol levels and higher baseline metabolic rate