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Because Semaglutide is a peptide, it quickly degrades in the acidic environment of our stomach, Horn explains
Diabetes 58 , 469477 (2009)
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Kawatani, M., Itoi, K., Talukder, A
The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy
