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Do not exceed recommended dosage or take with other stimulants or alcohol

[DOI] [PMC free article] [PubMed] [Google Scholar] 260.Mark AL, Agassandian K, Morgan DA, Liu X, Cassell MD, Rahmouni K

Obeticholic acid (OCA), a different modified bile acid, activates the FXR in individuals and raises insulin sensitivity

Cutting back by even one or two cups of coffee a day can be enough to trigger a withdrawal headache, typically within a day or two of reducing intake
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Kato, M., Nishikawa, S., Ikehata, A., Dochi, K., Tani, T., Takahashi, T., & Tsuda, T