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Rybelsus is also used to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes mellitus who are at high risk for these events

Longer-term use should only occur under clinical supervision

The one exception is the phentermine-topiramate extended-release combination (Qsymia), which is a fixed-dose FDA-approved product the two drugs are taken together in a single capsule designed specifically for that purpose

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Extended data is available for this paper at 10.1038/s41591-024-02996-7