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GLP-1 has been implicated as a cause of the metabolic success of surgeries performed to correct obesity but research in genetic mouse models challenges this assumption
In terms of glycemic control, these agents affect glucose metabolism through distinct pathways: GLP-1RAs enhance glycemic control by stimulating glucose-dependent insulin secretion, while SGLT2is lower blood glucose levels by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion
Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art
It can lower blood sugar levels and alter cholesterol profiles
Muscle mass preservation during weight loss is important for metabolic health and functional capacity
, Mauran, L
