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Specifically, ER upregulates nuclear respiratory factor 1 (NRF-1), which in turn stimulates the expression of mitochondrial biogenesis regulators, including mitochondrial transcription factor A (TFAM), and multiple subunits of the mitochondrial respiratory chain (MRC)

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While weight loss contributes, several direct physiological actions play a major role

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GIP also increases insulin biosynthesis (49), promotes -cell proliferation and inhibits -cell apoptosis (51)

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