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[DOI] [PMC free article] [PubMed] [Google Scholar] 299.Touvier M, da Costa Louzada ML, Mozaffarian D, Baker P, Juul F, Srour B

Because it exerts its effects around the clock, its just as good (or better) than insulin at regulating blood sugar and in clinical trials evokes more potent weight loss than either of its short-acting counterparts

(2022) in Cell Metabolism provides the foundational discovery data

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Below are the primary causes of plateaus: Losing the final 20 pounds (or 5 or 40 depending on starting weight) is often slower than early weight loss due to intensified metabolic adaptation

An overdose of Januvia can result in heart palpitations, tremors, excessive sweating, and even alterations in mental activity