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Common side effects include: Nausea Vomiting Diarrhea Indigestion These side effects usually subside after the first few weeks of treatment as your body adjusts to the medication

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This is biology, not failure Each cycle may become slightly less effective

Tirzepatide with B12 is popular because GLP-1 medications can sometimes reduce absorption of certain vitamins, and B12 deficiency is associated with fatigue, a side effect some tirzepatide users report

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in conjunction with diet and exercise, may reduce the effectiveness of oral contraceptives in those who are overweight