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GLP-1s impact digestion, vagal tone, appetite signaling, bowel motility, and cardiometabolic markers, and they interact with stress physiology and immune activation in ways that can either support or destabilize clients already navigating complex chronic conditions

and to the critical revision of the manuscript for important intellectual content

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Because appetite is reduced with these medicines, there is a risk of not eating enough essential nutrients, especially protein, which may cause muscle loss and low energy if not planned properly

B12 is essential for energy metabolism, and since these medications can sometimes limit nutrient absorption through reduced food intake, supplementation can be a helpful tool

The clinical evidence linking GLP-1 medications to persistent gastroparesis remains evolving and somewhat controversial