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The least square mean (LSM) change in HbA1c from baseline at week 52 was 2.4%, 2.6% and 2.8% with tirzepatide 5 mg, 10 mg, and 15 mg, respectively, versus 1.3% with dulaglutide

#GLP1 #Neuroscience academic.oup.com/jes/article/9/ GLP-1 receptors in reward-related brain areas (e.g., nucleus accumbens, insula) and the hindbrain allow GLP-1 and its agonists to regulate appetiteeven when hypothalamic structures are damaged by tumors

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