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however, no safe and efficacious pharmacotherapy is approved for obesity so far

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Bei langfristiger GLP-1-Anwendung kann eine dauerhafte Ergnzung sinnvoll sein

Glatter: Additional approaches to lose weight and manage cardiometabolic aspects of obesity include adherence to the Mediterranean, DASH, or MIND diet, along with adequate strength training, close monitoring of hydration status, and caloric intake to maintain and prevent muscle loss, particularly while taking a GLP-1

The binding of GLP-1 (or semaglutide) to GLP-1 receptors activates several biological responses: Increased insulin secretion after food intake, which improves blood glucose levels Reduced glucagon secretion, which limits glucose in the blood and helps reduce spikes in blood sugar Slowed emptying of the stomach, which helps people feel less hungry during the day Suppressed appetite, which again helps with feelings of satiety All of these factors promote sustained food (and therefore calorie) reduction, supporting weight loss with time