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Clinical studies show that many people regain some or most of the weight they lost if they stop taking tirzepatide

This may lead to lipotoxicity via activation of inflammatory pathways and production of inflammatory adipocytokines such as TNF-, plasminogen activator inhibitor 1, retinol-binding protein 4, and resistin which disrupt glucose disposal [12, 13]

Cardiovascular outcomes (e.g., SELECT and SOUL trials), 2

Looking forward, federal developments could shift states back toward coverage: the November 2025 announcement of most-favored-nation pricing and CMSs BALANCE model will likely make these drugs more affordable for state Medicaid programs, potentially improving short-term cost-effectiveness

others notice little change until dose increases occur

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