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This comparison therefore asks a focused question: does adding amylin receptor agonism to semaglutide meaningfully improve outcomes

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In November 2023, the FDA granted approval for tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to a reduced-calorie diet and increased physical activity

The extra time at each step does not reduce the eventual effectiveness of higher doses

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9 But like any other medication, it can come with some side effects