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Providers should also monitor renal function and gastrointestinal side effects during follow-up

However, when researchers compared these findings to lifestyle-driven interventions, the contrast was striking

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Concomitant use of dipeptidyl-peptidase-4 inhibitors (DPP-4) is not recommended because they have a similar basis of action

GLP-1 Safety Disclaimer: GLP-1 receptor agonist medications carry documented safety information including risk of pancreatitis, gallbladder disease, acute kidney injury, hypoglycemia (particularly in combination with insulin or sulfonylureas), serious hypersensitivity reactions, and for FDA-approved tirzepatide and semaglutide products a Boxed Warning regarding risk of thyroid C-cell tumors