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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Eng J., Kleinman W.A., Singh L., Singh G., Raufman J.P

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18 Molecular Modifications for Improved Stability and Half-Life While modifying GLP-1 receptor agonists to resist DPP-IV can extend their half-life, renal clearance still limits the duration of most peptidic agonists like exenatide and lixisenatide