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Several factors contribute to how fast semaglutide starts working

This makes retatrutide a focus of newer metabolic research

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So this is an area where there is a need to develop new treatments. Mahavir Agarwal, a psychiatrist who coleads the Mental Health and Metabolism Clinic at the Centre for Addiction and Mental Health, says GLP-1 drugs are worth investigating if only for antipsychotic side effect management in people with psychiatric conditions

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The 98-participant trial used liver fat measured by MRI-PDFF as the primary endpoint at 24 weeks and reported statistically significant mean relative reductions in liver fat across retatrutide groups relative to placebo, which the authors characterized as hypothesis-generating