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Around 11 percent of patients on the highest dose of retatrutide discontinued the drug due to adverse events in Lillys trial, compared to around 7 percent of patients in the pivotal trials for other drugs

Exendin-4 acts as a GLP-1 receptor agonist and served as the foundation for the pharmaceutical formulation marketed as exenatide, sold under the brand name Byetta by AstraZeneca in 2005 and later by Bristol-Myers Squibb

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Some plans cover semaglutide (Wegovy) or tirzepatide (Zepbound) with copays of $25-$300/month, but many plans dont cover weight loss medications or require extensive prior authorization

When disclosing semaglutide use for a drug test, ensure this information is handled confidentially