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Sulphonylureas and insulin usage, for instance, can elevate the possibility of low blood glucose, while gain in weight is commonly observed with insulin, sulphonylureas, and thiazolidinediones

Cardiovascular Outcomes This section reviews current evidence regarding GLP-1 RAs effects on MACE, PAD, CAD, HF, blood pressure, and AF, with detailed findings of trials and meta-analyses discussed in Tables 1 and 2 Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

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JAMA Surgery study of 1,046 patients identified independent risk factors for food retention with GLP-1 RA use (odds ratio 9.19, 95% confidence interval 2.7330.8), with tirzepatide demonstrating the strongest association amongst available agents [33]

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