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doi: 10.1186/s12915-017-0462-7 106 ZhouQ.VerneM

no SAEs were reported

Occasional digestive upset can occur even in long-term users, typically triggered by dietary indiscretions, stress, or other factors unrelated to the medication

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When weight is lost rapidly, the skin does not always keep pace, leaving the face and body looking less firm, less defined, and sometimes older than before