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People at higher starting weights tend to lose more total weight

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Assessment of confirmed bipolar disorder Assessment of the current episode must include an evaluation of the severity, polarity, risk of suicide, agitation, presence of psychotic symptoms, and functional impairment [Table 1]

They talk about this a bit, but make the (odd, to me, at least) choice to compare the 104-week SELECT (cardiovascular) trial to the 68-week STEP 1 (weight loss) trial, rather than the 104-week STEP 5 (weight loss) Trial

Harvard researchers found that taking the drugs led to a reversal of liver scarring due to metabolic dysfunctionassociated steatotic liver disease, also known as MASH. The scarring is one of the most common reasons for liver transplants