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2), implying a conserved receptor-ligandbinding mechanism (Parthier et al., 2009)

The key difference is that tirzepatide is FDA-approved and commercially available as Mounjaro and Zepbound (~$1,000$1,100/month cash, or $25+ with insurance and savings cards)

However, the structured dose titration protocols used in trials are absent in self-administration scenarios, significantly increasing the likelihood and severity of these reactions

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Briefing will be completed on February 25, 2025
