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In hyperglycemic rats, SGLT2 inhibitor, canagliflozin, can also inhibit intestinal SGLT1, which is the primary transporter for glucose and galactose, to elevate plasma active GLP-1 level and reduce post-prandial glucose (108)

2017 Feb;13(2):659-665

In some cases, nausea, fatigue, headache, and gastric discomfort are reported

But until now, PCSK9 inhibitors were only available as expensive injections taken every two weeks

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Transdermal products can cause local skin irritation, contact dermatitis, erythema (redness), pruritus (itching), or allergic sensitisation at the application site