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Severe gastrointestinal disease may worsen with incretin therapy

Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, unrelenting abdominal pain Signs of severe dehydration with confusion or altered consciousness Persistent vomiting with inability to retain any fluids for more than 24 hours Chest pain or difficulty breathing alongside gastrointestinal symptoms For patients with diabetes taking GLP-1 medications, persistent vomiting poses additional risks

GLP-1 receptors in the brain regulate thirst as well as hunger

Sellam, J

Calanna S, Christensen M, Holst JJ, Laferrre B, Gluud LL, Vilsbll T, Knop FK

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