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Leptin gene therapy in the fight against diabetes

Notes: (1) For the sake of simplicity, this article refers to these agents as GLP-1 agonists, even though Mounjaro (tirzepatide) and Zepbound (tirzepatide) are dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) agonists

563:S33

Sex Differences in CNS Actions of GLP-1: Preclinical Evidence While there are significant sex differences in the feeding responses elicited by different CNS GLP-1R populations, the extent and directionality of the uncovered differences depend on the neuroanatomical location of the GLP-1R population

National and Regional Trends in the Prevalence of Polycystic Ovary Syndrome since 1990 within Europe: The Modeled Estimates from the Global Burden of Disease Study 2016

Both GLP-1 and GIP are natural hormones that: By mimicking both hormones, tirzepatide may provide additional benefits for glycemic control and weight loss beyond those of single-agonist medications like semaglutide
