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doi:10.2337/dc10-2415 Fatty liver disease
The future of GLP-1 drug delivery is not just about efficacy it is about responsibility

Why its different Unlike semaglutide, which targets only GLP-1, tirzepatide works on both GLP-1 and GIP receptors

When a medication remains investigational, clinicians may not yet have complete information regarding long-term safety, rare adverse events, optimal dosing, or product consistency

The more frequent injection site reactions with exenatide once weekly (22%) compared with semaglutide (1.2%) in SUSTAIN-3 could be a consequence of this ( The head-to-head studies within the SUSTAIN and PIONEER programs allow some comparison of the adverse effect profile ( Table 2 )
