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The study also estimates that this genetic variation began developing about 20 000 years ago, in order to account for their high intake of polyunsaturated fatty acids from fish and sea food

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While they do contribute to fluid intake, caffeine has mild diuretic properties and can irritate the bladder lining, which is counterproductive for UTI prevention

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Collectively, these data suggest that FFAs increase intracellular Ca 2+ by stimulating the influx of Ca 2+ via the cell-surface (most likely L-type) Ca 2+ channels [292]