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Cyanocobalamin and especially methylcobalamin are photosensitive, meaning light energy can break down their molecular structure

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These include foods that are soft, low in fiber, cooked, and/or not spicy

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Some may start with even lower doses if compounded formulations are available

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Women using oral contraceptives should use an alternative or backup method for 4 weeks after tirzepatide initiation and with each dose increase due to potential reduced contraceptive effectiveness

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Tirzepatide causes gastrointestinal side effects somewhat more frequently than semaglutide, likely due to its dual GLP-1/GIP action versus semaglutides single GLP-1 action

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This changes the charge and shape of the peptide at that position

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