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We reported a case with severe MASH whose condition had ameliorated by switching from conventional GLP-1RAs to tirzepatide

GLP-1 analogues possess anti-catabolic activity, as demonstrated by reduced MMP-3 and MMP-13 , ADAMTS4 , ADAMTS5 mRNA expression in TNF-stimulated human chondrocytes that was correlated with increased aggrecan and type II collagen protein levels [42,43]

doi: 10.3389/fcdhc.2025.1590530 Received 09 March 2025 Accepted 18 June 2025 Published 10 July 2025 Volume 6 - 2025 Edited by Angelo Maria Patti, University of Palermo, Italy Reviewed by Anapaula Sommer Vinagre, Federal University of Rio Grande do Sul, Brazil Jun Eguchi, Okayama University, Japan Updates Copyright 2025 Hammad, Zafar, Ullah, Faisal, Iftikhar, Waheed, Muzaffar, Ahmed, Ashraf, Zahid, Akhtar and Mahmmoud Fadelallah Eljack

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