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For athletes, the implications are significant

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When the steroid is stopped, the suppressed inflammation surfaces in full, causing a flare within two to five days

These findings suggest that simultaneously targeting multiple regulatory nodes may yield superior therapeutic outcomes

and by prior HF (NYHA Class IIII, yes/no).39 The HRs favoured liraglutide versus placebo in all subgroups, apart from the subgroups at lowest CV risk in the former two analyses.37, 38, 39 The interaction of CV risk status at baseline on the treatment effect of liraglutide was not significant in any analysis, suggesting consistent CV effects across clinically relevant subgroups.37, 38 These findings may seem inconsistent with a prespecified subgroup analysis of LEADER, in which a significant interaction of treatment effect on MACE was observed in those aged 50 years with established CVD or CKD versus those aged 60 years with risk factors for CVD.2 However, considering the broad 95% CI in the CV risk factor only subgroup (0.86, 1.67), further study is warranted