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Drug Interactions The concomitant use of JANUMET with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see Drug Interactions (7)]

Black: Black poop can be a sign of too much or iron or bismuth in the body as well as bleeding in the upper gastrointestinal tract

Others still experienced symptoms at trial endpoint

Thus, further large-scale prospective studies are necessary to elucidate the risk of gastrointestinal adverse events in different patient populations, particularly with respect to personalized treatment strategies for high-risk groups, including sex-specific analyses to address potential differences in nausea and vomiting susceptibility

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The dose magnitude is different