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Diabetes & Metabolism Journal 44:248259

PlexusDx's Precision Peptide Genetic Test identifies variants in GLP1R, GIPR, FTO, and MC4R genes that directly influence how well semaglutide suppresses your appetite and how quickly you'll lose weight at each dose

After reviewing the data I laid out in the sections above, here is how I think about the decision

According to the UK SmPC, Wegovy is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis , as it may worsen existing symptoms

Many people benefit, some do not, and thats normal

Swallow it whole with a small sip of plain water (no more than 120ml), then wait at least 30 minutes before eating, drinking or taking other medicines