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Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks

In experimental models, a loss of MAGEL2 expression disrupts the normal response of POMC neurons to leptin, leading to increased food intake and uncontrolled fat storage (154, 155)

Elkind-Hirsch, K

Likewise, GLP-1RAs can lower postprandial glycemia predominantly by slowing gastric emptying and promoting weight loss [6, 7]

Future pharmacotherapy for obesity: New anti-obesity drugs on the horizon

Once it reaches the bloodstream, it is directly inactivated within seconds by the enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between positions 8 and 9, converting it into the truncated form GLP-1(936) amide