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Diabetes Care 2024;47(Suppl 1):S15878
That said, while early clinical experience is promising, microdosing hasnt been formally studied in large trials and isnt FDA-approved

Combined oral contraceptive pills are often used to manage menstrual irregularity and androgen-related symptoms, while metformin is commonly prescribed to address insulin resistance and other metabolic issues ( 13 )

The system is overprotective by evolutionary design -- the cost of failing to detect a poison is death, while accidentally rejecting a safe but bitter food just means eating slightly less, which isn't serious
Neuroendocrinology 94 , 291301 (2011)

And when she's on that pickleball court, she is really working hard, and she's traveling and she's going out and she's being physically active and using the stairs