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The expression of the growth factor independence1 (Gfi1) transcription factor in Paneth and Goblet cell precursors prevents their conversion into EEC lineage [21]
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Best JH, Boye KS, Rubin RR, Cao D, Kim TH, Peyrot M

Specifically, this activation effect is mainly reflected in two aspects: it further activates the downstream mTOR molecules through the Akt-mTOR axis, directly promoting the synthesis of muscle proteins and inhibits the binding of the myostatin promoter, thereby reducing the expression of myostatin and ultimately alleviating muscle atrophy