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Treatment of HFpEF beyond the SGLT2-Is: Does the addition of GLP-1 RA improve cardiometabolic risk and outcomes in diabetic patients
It is an artificial peptide-based variant of exendin- 4, an incretin mimetic [87]
Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity
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This refined understanding of DR as an immunoinflammatory disease provides a strong rationale for exploring immunomodulatory agents like GLP-1RAs
