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In conclusion, our study reveals that among matched individuals with type 2 diabetes followed by Italian diabetes specialists, initiation of an SGLT2i was associated with less decline in eGFR over time, with higher eGFR values and less negative eGFR slopes compared with GLP-1RA initiation

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5,6 Thus, new T2D pharmacotherapy guidelines have recommended the use of GLP-1RAs for prevention and treatment of obese patients with risks of atherosclerotic cardiovascular diseases, whereas SGLT-2is has been proposed for patients with a risk of chronic heart failure