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Beyond FDA-approved pathways, some qualified providers prescribe compounded semaglutide to adolescents with severe obesity and failed lifestyle interventions, supported by emerging clinical evidence

Avoid strenuous activities, heavy lifting, and abdominal strain for 46 weeks

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A 2022 review in Gastroenterology looked at GLP-1 agonist use across multiple trials and found a roughly two-fold increase in acute pancreatitis risk compared to placebo

Studies of tirzepatide in chronic kidney disease and in morbidity/mortality in obesity continue

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