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Higher doses of retatrutide produced significant weight loss, with Phase 2 trials reporting average reductions of about 24% of body weight after 48 weeks

Importantly, neural circuits in humans are much more sophisticated than those in mice

Patients running a 16:8 fasting window who inject MOTS-C first thing in the morning often report the most consistent results, though I want to flag that I havent run a controlled comparison and this is mostly pattern recognition
"Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial." New England Journal of Medicine , 2023;389:514526

These drugs have different formulations and dosing schedules
