semaglutide liver side effects CONS: ⚠️ Gastrointestinal effects: Nausea, vomiting, diarrhea, and constipation affect approximately 50-60% of patients, especially during initial treatment. ⚠️ Muscle loss: Up to 39% of weight lost may come from lean Metabolic dysfunction-associated steatotic liver disease
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Conversely, inhibiting p38 MAPK reduces inflammation and fibrosis, potentially improving kidney function [79]
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