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For perspective, prior to 2023, the top-selling drugs were largely immunology or oncology biologics (like Humira, Keytruda, Eliquis), but by mid-2024, the list transformed GLP-1 agonists entered the top ranks

These effects often diminish as patients adjust to medication

Cell Metab 36(7):1534-1549.e1537

JCI Insight (2020) 5(17):e140532

For example, a pharmacy may make a liquid version of a drug that only comes in pill form for a patient who has trouble swallowing

Metabolic Flexibility and Substrate Utilization Dual agonism may promote greater metabolic flexibility by influencing both glucose and lipid metabolism through complementary mechanisms