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Front Genet 2021;12:625564

The onset of SYGL-1 expression relies on Notch signaling from the niche, which activates sygl-1 transcription [18, 19], but we thought its distribution might be refined post-transcriptionally since genome-wide studies identified RNA regulatory proteins binding to the sygl-1 3UTR [26, 27]

Discussion We successfully switched an acromegaly patient with pasireotide-induced deterioration of glycemic control from a DPP-4 inhibitor to a GLP-1 analog

Managing the Transition Period After Stopping Gradual dose reduction rather than abrupt discontinuation may help reduce rebound GI symptoms in some patients, though clinical guidance on tapering is still evolving

B., Cuervo, A

Trahair LG, Nauck MA, Wu T, et al