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The delayed release of Amarasate bitter extract in the upper duodenum stimulates the activation of TAS2R receptors on enteroendocrine cells to release GLP-1, CCK and PYY (appetite suppressing hormones)

This can cause chemical pneumonitis, bacterial pneumonia, or airway complications

Dietary modifications form the foundation of constipation management: Increase fiber intake : Aim for 25-30 grams daily through whole grains, fruits, vegetables, and legumes

Aim for a combination of cardiovascular exercise and resistance training in line with NHS physical activity guidelines

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