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When they first came to market for diabetes, they noticed a side effect was weight loss. A potentially complex treatment option The patient side of the equation can be complex, as some experts believe these medications, whether for diabetes or weight loss, may need to be taken throughout a persons life, as a direct treatment or maintenance therapy

Getting this wrong can mean under-dosing (wasting money and getting suboptimal results) or over-dosing (increasing side effects unnecessarily)

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Other notable side effects include: Injection site reactions such as redness, itching, or bruising at the injection site Fatigue some patients report feeling more tired than usual Hypoglycaemia low blood sugar is uncommon with Ozempic alone but may occur when used alongside insulin or sulfonylureas (doses of these medications may need adjustment by your prescriber) Important safety warnings from the UK SmPC include: Acute pancreatitis seek immediate medical attention for severe, persistent abdominal pain, with or without vomiting Gallbladder disease including gallstones and inflammation of the gallbladder Diabetic retinopathy complications particularly in patients with pre-existing retinopathy when blood glucose improves rapidly Dehydration and kidney problems severe gastrointestinal side effects may lead to dehydration and acute kidney injury Hypersensitivity reactions including rash, itching and rarely, anaphylactic reactions It is important to note that swollen lymph nodes are not listed among the recognised side effects of Ozempic in the UK SmPC or patient information leaflet

These findings indicate that the attenuation of diabetic vascular calcification (DVC) by Semaglutide is associated with the inhibition of CPNE1-mediated autophagy, suggesting a potential novel therapeutic strategy for managing DVC