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doi: 10.1210/jcem.81.2.8636267 58 AbsRMattssonAThunanderMVerhelstJGothMWiltonPet al
Chronic stress and elevated cortisol blunt GLP-1 and insulin responsiveness
Research demonstrates that omega-3 supplementation can reduce DPP-4 activity, though the mechanism appears to be through anti-inflammatory pathways rather than direct enzyme inhibition
Eli Lilly, Novo Nordisk, Boehringer Ingelheim, Takeda Pharmaceutical, Merck & Co., and AstraZeneca
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Second, the cognate receptor must be known or plausibly identifiable, enabling mechanistic interrogation and rational drug design
