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[Google Scholar] [17].Fernndez-Ruiz I, SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes, Nature Reviews Cardiology (2023)

Those who took a GLP-1 had a lower risk of complications, including progression to proliferative diabetic retinopathy, diabetic macular edema, vitreous hemorrhage, and neovascular glaucoma

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This did not appear to be through changes to signal bias, as BETP at this dose did not affect cAMP or -arrestin-2 recruitment responses (Fig

This binding activates several intracellular pathways, including the JAK-STAT pathway, which influences the expression of neuropeptides that regulate feeding behaviour