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Using #TargetTrialEmulation across 703 clinical practices, we examined over 23,000 patients aged 45+ from 20192024 - we found Semaglutide was associated with a lower risk of @MACE (primarily driven by stroke) compared to empagliflozin Dulaglutide and empagliflozin had similar cardiovascular outcomes Hypothesis generating signal of semaglutide's more profound effect in 65 years and younger patients which needs to be looked at in future studies