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Description
After systemic administration, they engage both GLP1R and GIPR simultaneously in native tissue, enabling the study of receptor engagement, metabolic responses, and therapeutic effects at the cellular and organ level, going beyond localization to provide functional readouts directly in living models

It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40

Target Indication Insights Why did the type 2 diabetes segment dominate the obesity GLP-1 market

Other health benefits of GLP-1s The potential health benefits of GLP-1s go beyond weight loss and blood sugar control

Luger, A

A single skin administration of a PSR-MNs patch (2 cm 2 cm) which contains 4 programmable core-shell MNs patches (1 cm 2 each, so-called pixels) enables the repeated release of Semaglutide every 7 days and sustains the drug efficacy for an unprecedented one-month period, simulating the effect of using four bolus injections spaced 7 days apart
