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Conclusions These data demonstrate for the first time the potent effect of semaglutide in reducing voluntary alcohol intake in non-human primates and further substantiate the need for clinical trials investigating the effect of semaglutide in patients with alcohol-use disorder.

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The broader implications of these findings are that the LH differs between females and males in its ability to control motivated and ingestive behaviors.

Purpose of Review This review provides a comprehensive and scholarly examination of glucagon-like peptide-1 receptor (GLP-1R) agonists, tracing their evolution from glycemic control agents in diabetes mellitus (DM) to multifaceted therapeutics with expanding indications in cardiovascular, renal, and metabolic health

If you are on a GLP-1 medication and noticing fatigue, muscle tightness, or changes in how your body feels, you are not alone